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KMID : 0358419750180100843
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Korean Journal of Obstetrics and Gynecology
1975 Volume.18 No. 10 p.843 ~ p.863
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Characterization of Immunologic and Biologic Activity of Antisera aganist Bovine Luteinization Hormone and Bovine Thyroid stimulating hormone
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김승조/Kim SJ
최성기/나종구/정구윤/남궁성은/김수형/Choi SK/Rha CG/Chung KY/Namkoog SE/Kim SP
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Abstract
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Although major contributions to protein structure have been made by studies on such protein and carbohydrate containing hormones of the pituitary gland, thyrotropin(TSH), luteinizing hormone (LH or ICSH) and related placental glycoproteins, presents chemists and endocrinologists with more difficulties Certainly of major biological importance and of possible importance in clinical investigation is the discovery that one of the TSH chains TSH-a is so similar to one of the chains of LH, the LH-a chain , that they are indistinguishable in amino acid composition and probably, in amino acid sequence These similar chemical and physical properties of the two hormonoes perphaps make immunological cross reaction with some antisera to TSH and LH in vivo. petrusz et al. had made the polymorphism of protein hormone as antigen, clear by doing the biological assay for the neutralizing potency of the anti-gonadotropin serum. Lauternce and Kim investiaged that the biological action and histochemical activity in the ovary was restrained as the endogenous LH is neutralized in the rats and rabbits as the result of passive immunization with anti-LH serum Rats have two clear peak of progesterone release at proestrus and diestrus. High peak of progesterone concentration usually occur about 2 hours after LH surge during proestrus in the rats. The present experiment were desinged to determined how anti-LH and TSH antibody would react with endogenous hormones in the rat and would alter the reproductive system of the treated animals, and how was differences between Anti-LH and Anti-TSH serum on immunologic neutralizing potency of endogenous TSH in the mice and progesterone synthesis in the antibody treated rats.
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